ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Genome polyprotein

Intermolecular
Cysteine 188 of HLA class I histocompatibility antigen, A alpha chain and cysteine 1073 L
Cysteine 125 of HLA class I histocompatibility antigen, A alpha chain and cysteine 1073
A redox-regulated disulphide may form between cysteine 188 of HLA class I histocompatibility antigen, A alpha chain and cysteine 1073 of Genome polyprotein (164 and 1 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
3mrh
Structure name
crystal structure of mhc class i hla-a2 molecule complexed with hcv ns3-1073-1081 nonapeptide n3s variant
Structure deposition date
2010-04-29
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
HLA class I histocompatibility antigen, A alpha chain
Peptide B name
Genome polyprotein
Peptide A accession
P01892
Peptide B accession
Q03463
Peptide A residue number
188
Peptide B residue number
1073

Ligandability

Cysteine 188 of HLA class I histocompatibility antigen, A alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1073 of Genome polyprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 125 of HLA class I histocompatibility antigen, A alpha chain and cysteine 1073 of Genome polyprotein (101 and 1 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
3mrh
Structure name
crystal structure of mhc class i hla-a2 molecule complexed with hcv ns3-1073-1081 nonapeptide n3s variant
Structure deposition date
2010-04-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
HLA class I histocompatibility antigen, A alpha chain
Peptide B name
Genome polyprotein
Peptide A accession
P01892
Peptide B accession
Q03463
Peptide A residue number
125
Peptide B residue number
1073

Ligandability

Cysteine 125 of HLA class I histocompatibility antigen, A alpha chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1073 of Genome polyprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: